ELEVATED INFLAMMATORY RESPONSES AND TARGETED THERAPEUTIC INTERVENTION IN A PRECLINICAL MOUSE MODEL OF ATAXIA-TELANGIECTASIA LUNG DISEASE

Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease

Abstract Ataxia-telangiectasia (A-T) sound anchor adj2 is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects.A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the lung complications are poorly understood, and

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Impacts of population structure and analytical models in genome-wide association studies of complex traits in forest trees: a case study in Eucalyptus globulus.

The promise of association reebok classic grün genetics to identify genes or genomic regions controlling complex traits has generated a flurry of interest.Such phenotype-genotype associations could be useful to accelerate tree breeding cycles, increase precision and selection intensity for late expressing, low heritability traits.However, the pros

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Cuminaldehyde ameliorates hyperglycemia in diabetic mice

Background: Animal-fats j??kaapin raikastin are rich in long-chain saturated fatty-acids, well known to induct diabetic distress among ingested insulin-insensitive individuals.In the current-study, bovine-fat was fed to selective mice breeds highly sensitized to heavy dietary lipid load.Methods: The later high fat diet (HFD) group indeed undergone

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